When you're deep in the lab, or perhaps just curious about the building blocks of modern chemistry, you might come across a specific identifier: a product number. For 2-fluorophenylboronic acid, a compound that plays a surprisingly significant role in various scientific fields, understanding its identity goes beyond a simple code. Let's dive into what makes this molecule tick.
At its heart, 2-fluorophenylboronic acid is a member of the organoboron family, specifically a phenylboronic acid derivative. The '2-fluoro' part tells us there's a fluorine atom attached to the benzene ring at the position adjacent to where the boronic acid group is connected. This seemingly small addition of a fluorine atom is quite impactful. Fluorine is known for its strong electron-withdrawing nature, and when it's placed on the benzene ring, it can subtly but significantly alter the electronic properties of the entire molecule. This can lead to enhanced stability and interesting dielectric properties, which are crucial in fields like materials science.
Its applications are quite broad, stretching into organic synthesis, where it acts as a versatile building block. It's also found its way into biomedical research, contributing to the development of new pharmaceuticals. And in the realm of materials science, particularly in the creation of liquid crystal displays (LCDs), its unique properties are highly valued.
For those working with it, knowing its CAS number, 1993-03-9, is like having a universal passport. It's the unique identifier that ensures you're talking about the exact same chemical entity, regardless of language or region. The English name, 2-fluorophenylboronic acid, and its various synonyms like 'o-fluorophenylboronic acid' or even 'vonoprazan impurity 215' (indicating its presence as a byproduct or intermediate in the synthesis of certain drugs) all point back to this one specific compound.
Chemically, it presents as a white to light yellow crystalline powder. It has a melting point typically between 101-110°C. While it's soluble in methanol, its storage conditions are important: keep it in a dark, dry place at room temperature to maintain its integrity. The 'acid' in its name isn't just for show; it has a predicted pKa of around 8.32, meaning it behaves as a weak acid.
Producing 2-fluorophenylboronic acid involves a specific chemical process. A common method starts with ortho-fluorobromobenzene, cooled to very low temperatures. Then, reagents like n-butyllithium and triisopropyl borate are carefully added, followed by an acidic workup. This multi-step synthesis, yielding around 85% of the desired product, highlights the precision required in chemical manufacturing.
When you're looking to purchase it, you'll find it listed under various product numbers depending on the supplier. For instance, TCI (Tokyo Chemical Industry) might list it with a specific internal code, like 'f0407' for their reagent grade. Prices can vary based on quantity and purity, with smaller amounts like 1g costing around 50 yuan, and 5g going for about 190 yuan. Globally, there are hundreds of suppliers, from large chemical corporations to specialized distributors, all ensuring this valuable compound is accessible for research and industrial use.
Understanding 2-fluorophenylboronic acid, from its chemical structure and properties to its synthesis and market availability, reveals the intricate world of chemical compounds that underpin so much of our modern technology and medicine. It’s a reminder that behind every product number is a story of molecular design and scientific application.
