(R)-1-(4-Methylphenyl)ethylamine: Comprehensive Applications and Technical Characteristics Study
Basic Information and Structural Properties of the Compound
(R)-1-(4-Methylphenyl)ethylamine, as an optically active organic amine compound, exhibits unique stereochemical characteristics in its molecular structure. The chemical formula of this compound is C9H13N, with a molecular weight of 135.206 g/mol, belonging to aromatic amine derivatives. From the perspective of molecular structure, its core framework consists of a para-methyl-substituted benzene ring connected to an ethylamine group via a carbon-carbon single bond; this structure imparts specific electronic effects and steric hindrance properties to the molecule.
In terms of physical properties, this compound appears as a colorless to pale yellow transparent liquid at room temperature, with a relative density of 0.9±0.1 g/cm3. Its boiling point reaches 208.6±9.0°C (760 mmHg), while the melting point is below -20°C; this wide liquid temperature range provides significant advantages for industrial applications. Notably, the refractive index of this compound is 1.530; this optical parameter holds important reference value for its applications in chiral recognition and optical materials fields.
Chemical Nomenclature and Identification System
This compound has multiple standard names within chemical nomenclature systems. According to IUPAC naming rules, it is systematically named (R)-(+) -1-(4-methylphenyl)ethylamine. In Chinese nomenclature systems, it is standardized as (R)-1-(4-甲基苯基)乙胺 but also commonly referred to by other aliases such as (R)-(+) -1-(对甲苯基)乙胺 in academic literature and industrial practice—all referring to the same chemical entity.
In terms of chemical identification systems, the CAS registration number for this compound is 4187-38-6; this unique numerical identifier plays a crucial role in international chemicals trade and regulatory documents. Additionally, its precise molecular mass stands at 135.104797 with a polar surface area (PSA) measuring 26.02000—parameters that are vital for understanding solubility and intermolecular interactions associated with it.The logP value for this compound being at 1.90 indicates moderate lipophilicity which directly influences its distribution and metabolic behavior within biological systems.
Analysis on Major Application Areas
Core Value in Medicinal Chemistry In medicinal chemistry field,(R)-1-(4-Methylphenyl)ethyamine demonstrates significant application value.This compound serves as key chiral building block widely used in asymmetric synthesis involving various bioactive molecules.Notably,it acts as critical intermediate for Y-39983,a novel anti-glaucoma drug developed by Mitsubishi Tanabe Pharma from Japan currently undergoing clinical phase II trials showing promising intraocular pressure-lowering efficacy along safety profile features. Besides ophthalmic drugs usage,this chiral amine participates actively during synthesis processes related towards several central nervous system medications.Its aromatic ring alongside amino functional groups provide necessary pharmacophore characteristics enhancing interaction between drug molecules targeting proteins.In pharmaceutical design researchers utilize rigid structures limiting conformational flexibility thereby improving selectivity stability metrics observed through statistics indicating approximately15%of new drug development projects involve such chiral amines intermediates recently.