New Quinoline Amide Fungicide: Research Progress and Application Prospects of Quinoline Amine
Product Overview and Chemical Properties
Quinoline amine (feneptamidoquin) is a new type of quinoline amide fungicide developed by the international agrochemical giant Syngenta in 2017. This compound, with its unique chemical structure and broad-spectrum antifungal activity, shows great application potential in plant disease control. As a representative of the new generation of fungicides, the development of quinoline amine marks a significant breakthrough in the agricultural application of quinolone compounds.
From a chemical structural perspective, quinoline amine is a mixture of stereoisomers primarily composed of (2R)-isomer (80-100%) and (2S)-isomer (20-0%). Its chemical name is N-(2R)-[1,3-dimethyl-1-(benzyl)butyl]-8-fluoro-3-quinolinamide mixed with N-(2S)-[1,3-dimethyl-1-(benzyl)butyl]-8-fluoro-3-quinolinamide. The molecular formula is C23H25FN2O with a relative molecular mass of 364.456. According to CAS registration numbers, the main component's registration number is 2132414-06-1; secondary component's registration number is 2132414-05-0; mixture registration number is 2132414-04-9.
In terms of physicochemical properties, under standard conditions (20°C,760torr), the density of quinoline amine active ingredient is 1.133±0.06g/cm³ with a boiling point as high as 561.1±40.0°C indicating high thermal stability. Its pKa value stands at 13.27±0.46(25°C), suggesting that this compound can maintain stable chemical properties in conventional agricultural applications environment. These excellent physicochemical parameters provide solid chemical foundations for its stability during field applications.
Antifungal Spectrum and Action Characteristics
Quinoline amine exhibits remarkable broad-spectrum antifungal activity supported by extensive indoor bioassays and field trial data showing significant inhibitory effects against various plant pathogens including but not limited to Botrytis cinerea, Fusarium spp., Septoria spp., Magnaporthe oryzae as well as Gaeumannomyces graminis among others causing severe agricultural losses globally while providing new solutions for controlling these diseases.
Notably, quinoline amine demonstrates excellent control efficacy against important crop diseases such as rice blast disease, barley net blotch disease, wheat leaf blight disease , wheat scab disease , grape gray mold disease , cucumber gray mold disease , gourd anthracnose , pear black spot disease , apple scab disease along with root rot . Although its action mechanism has yet to be fully elucidated based on its structural characteristics combined with biological activity performance it may significantly differ from existing fungicides’ targets making it promising tool for resistance management.
Regarding action characteristics，quino lineamine possesses both preventive actions alongside certain therapeutic activities.Field trials indicate that applying this agent early during onset effectively halts lesion expansion while also controlling newly occurring infections adequately.Additionally，its relatively long-lasting effect reduces frequency thus lowering labor costs & environmental pressure .
Application Technology & Formulation Development
Quin olineamine finds wide-ranging applicability across multiple key crop systems.In cereal crops,it displays outstanding protective effects against major diseases affecting wheat,barely,&rice ;while economically valuable crops like soybeans,corn etc benefit from pest management strategies employing this product.In horticultural contexts,various vegetables(cucumbers,gourds etc.)and fruits(grapes pears apples )can utilize effective pathogen controls provided through utilization techniques tailored specifically towards them . nFor diverse cropping systems&application scenarios,multiple formulations have been developed catering practical needs.A suspension concentrate containing25%of quino lineamine proves particularly suitable for foliar spraying due good coverage&adhesion qualities ;a water dispersible granule featuring20%of quino lineamine facilitates transport/storage convenience whilst being user-friendly;28%-microsuspension formulation employs advanced microencapsulation technology enabling sustained release prolonging effectiveness minimizing environmental impact.These varied formulation developments offer flexible choices regarding utilizing Quinol ineAmid e within different agricultural ecosystems . nDuring actual use case studies show Quinol ineAmid e maintains good safety profiles towards crops.Extensive field tests reveal no adverse impacts upon growth when utilized recommended dosages nor does it induce noticeable phytotoxic symptoms simultaneously low residue levels found comply modern standards ensuring quality assurance needed within green agriculture practices overall.. n### Combination Applications & Resistance Management To maximize efficacy derived from using Q uinol ineAmid e while delaying emergence resistant strains researchers devised numerous efficient combination schemes.Combinations involving fluopyram or difenoconazole exhibit notable synergistic enhancements tackling cucumber grey moulds according trial results demonstrating increased efficiency lowered single dosage requirements thereby mitigating pesticide residues risks extending lifespan pathogens resisting treatments applied over time .. In combating rice-related ailments combiningQ uinol ineAmid ew ith tricyclazole/difenoconazole showcases exceptional outcomes highlighting how blending distinct mechanisms yields substantial improvements accordingly.It’s essential approach allows reduced treatment frequencies total quantities used resulting lower production expenses/environmental burdens alike targeted issues faced farmers today! nParticularly concerning wheat fusarium head blight/rice blast therapy combinations leveraging pyraclostrobin/oxathiapiprolin perform excellently expanding spectrum preventing further risk associated developing resistances observed throughout history—numerous demonstration results validate scientifically designed partnerships yield higher success rates without inflating input costs protecting consumer interests too!Overall comprehensive analysis indicates thorough patent protections established around core components underpinning commercial viability assured future advancements forthcoming! n ### Patent Protection & Synthesis Process The core compound behindQ uinol ineAmid eis subject strict patent safeguards.The Chinese patent CN108697087A(application#CN201780015778).discloses detailed information surrounding antimicrobial-active derivatives inclusive thereof outlining chemistry structures/agricultural uses filed March seventh two thousand seventeen.Syngenta Ltd holds rights encompassing aspects related molecule design,synthesis methods/compositions applicable therein which ensures robust intellectual property security granted hereunder ! Within synthesis protocols disclosed patents outline pathways leading toward producingQ uinol ineamid starting materials include phenylpropanone/methanesulfonamide necessitating precise reaction condition monitoring ensure target stereoisomer ratios achieved directly impacting final products bioactivity optimization efforts undertaken demonstrate improved catalyst systems/reaction setups enhance yield/purity metrics respectively!.Beyond foundational compositions additional patents exist covering mixtures/formulations pertaining specifically aiding protection networks securing commercial endeavors successfully laid groundwork fostering continued innovation ahead!! Overall analysis suggests strategic positioning conducted viaSyngentain sector bolsters subsequent product development initiatives enhancing research capabilities going forward !! n ### Market Outlook & Development Directions As novel classifying agents exemplified herein represent immense opportunities poised seize market share driven policies aimed reducing reliance pesticides combating growing concerns arising resistance challenges confronted farmers worldwide needing innovative solutions available now more than ever before!Broad-spectrum efficacies coupled unexplored mechanisms signify potentials emerge crucial players fighting back threats posed traditional counterparts facing extinction soon enough unless proactive measures taken swiftly resolve situations promptly!!! Current stages suggest ongoing investigations necessary clarify specific operational dynamics informing assessments regarding risks entailed understanding larger implications beyond just simple usage guidelines optimizing benefits derived therefrom possible paths lie ahead unlocking true potentials realized sooner rather later depending circumstances prevailing factors influencing decisions made ultimately determine fates respective industries involved altogether!!!