Development and Technical Application Research of Detection Methods for Perfluorinated Compounds and Bisphenol A
Overview of Detection Methods for Perfluorinated Compounds
Perfluorinated compounds (PFCs) are a class of organic fluorides with significant industrial application value, where all hydrogen atoms on the carbon chain in their molecular structure are replaced by fluorine atoms. Due to their unique hydrophobic and oleophobic properties, these compounds are widely used in textiles, food packaging, firefighting foams, among many other fields. Currently, over 5,000 types of perfluorinated compounds have been identified; perfluoroalkyl acid (PFOA) and perfluorooctane sulfonate (PFOS) have attracted considerable attention due to their environmental persistence and bioaccumulation.
In terms of detection technology, liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the mainstream analytical method. This method effectively separates target substances from complex samples through high-performance liquid chromatography before achieving highly sensitive qualitative and quantitative analysis via tandem mass spectrometry. The current GB 31604.35-2016 standard adopted in China utilizes this method for detecting PFOA and PFOS. It is noteworthy that this method requires high technical proficiency from both equipment operators as well as specialized training support.
Detailed Explanation of PFOA and PFOS Detection Technologies
As typical representatives of perfluorinated compounds, the development of detection methods for PFOA and PFOS holds significant practical importance. In actual testing processes, sample pretreatment is a critical step. Common sample preparation methods include solid-phase extraction (SPE), liquid-liquid extraction (LLE), etc., which can effectively remove matrix interferences to enhance detection sensitivity.
Regarding instrument configuration, the combination system consisting of API 4000 tandem mass spectrometer with Agilent 1200 liquid chromatograph provides excellent analytical performance. The resolution capability reaches up to 0.7 Da with a detection limit at ppt levels—fully meeting the requirements for trace amounts of PFOA/PFOS in environmental samples or materials intended for food contact purposes. Method validation data indicates that recovery rates stabilize between 80%-120%, while relative standard deviation remains below 15%, demonstrating good accuracy and precision.
Research on Bisphenol A Detection Methods
Bisphenol A (BPA) is an important industrial chemical widely used in producing polycarbonate plastics as well as epoxy resins. Due to its potential endocrine-disrupting effects, strict regulatory limits have been established worldwide regarding its usage levels. Current testing standards within China include multiple methodological standards such as GB/T 38420-2019 & GB/T 38415-2019—all employing high-performance liquid chromatography-tandem mass spectrometry techniques.
The primary challenge faced during BPA detection lies within prevalent matrix interference issues since common materials like inner coatings from canned foods or thermal paper may contain BPA; thus requiring robust anti-interference capabilities within testing methodologies themselves.. By optimizing chromatographic conditions—for instance utilizing C18 reverse phase columns alongside methanol-water mobile phases undergoing gradient elution—it becomes feasible to separate BPA from interfering substances effectively . Mass spectral detections utilize Multiple Reaction Monitoring(MRM ) modes whereby characteristic ion pairs undergo quantification significantly enhancing specificity throughout methodology employed .
Technical Services & Personnel Training
Comprehensive technical service support constitutes an essential aspect ensuring quality assurance across analyses performed . Our dedicated team offers full-spectrum assistance ranging from instrument maintenance down through methodological developments inclusive preventive maintenance plans entailing regular calibrations along side systematic performance verifications capable reducing instances concerning equipment malfunctions substantially . Repair services deploy original manufacturer parts guaranteeing instruments revert back optimal operational states post repairs undertaken . nWhen it comes personnel training we adopt blended learning approaches combining theoretical instruction alongside hands-on practice sessions covering core topics including sample pre-treatment techniques ,instrument operation protocols ,data analysis strategies et cetera facilitating technicians’ rapid acquisition necessary skills required conducting tests accurately whilst particularly addressing challenging projects involving PFOA,P F OS&B PA providing tailored solutions assuring reliable outcomes generated during assessments conducted respectively ; n ### Overall Laboratory Solutions Provided: We offer comprehensive laboratory services encompassing instrumentation setup ,methodological validations,daily upkeep etc.; tailored flexible service options available accommodating varying scales laboratories ranging rental agreements relocations upon request accordingly! With respect developing new procedures our extensive experience enables us assist clients establishing compliant standardized test protocols expediting project timelines considerably ! Lab construction consultancy represents one specialty offered wherein customized configurations proposed based client specific demands/budgets ensuring optimized setups achieved efficiently!